^
Association details:
| Biomarker: | RRM2 overexpression |
|---|---|
| Cancer: | Hepatocellular Cancer |
| Drug: | tivantinib (ARQ 197) (c-MET inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Proliferation Markers Are Associated with MET Expression in Hepatocellular Carcinoma and Predict Tivantinib Sensitivity In Vitro
Excerpt:
Altogether, by combining results obtained with the two dose–response parameters GI50 and AUC, high mRNA expression of the three cell proliferation genes, CDC20, RRM2, and GMNN, emerged as the best predictor of tivantinib sensitivity.
DOI:
10.1158/1078-0432.CCR-16-3118
