We present the case of ROS1- rearranged lung cancer successfully resected after response to crizotinib….ROS1 rearrangement was detected by reverse transcriptase polymerase chain reaction. The patient was diagnosed with ROS1-rearranged lung adenocarcinoma (cT4N2M0, stage IIIB) and was treated with crizotinib (250 mg twice daily) as first-line chemotherapy. After 8 weeks of treatment, chest CT showed a significant decrease in the size of the tumor and lymph nodes (Fig. 1e, d), especially mediastinal lymph nodes were markedly reduced.