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Association details:
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Title:

A Phase 1b Dose-Escalation Study of Encorafenib (LGX818) and Cetuximab With or Without Alpelisib in Metastatic BRAF-Mutant Colorectal Cancer

Excerpt:
Seventeen patients (81%) had Ring Finger Protein 43 (RNF43) alterations, and the majority, eleven patients, was treated with the dual-combination. These 11 patients had a median of 112 days of PFS (range, 1 to 589), with three patients having a PR and one a CR.
DOI:
10.1158/2159-8290.CD-16-0795
Trial ID: