^
Association details:
| Biomarker: | RB1 mutation |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | Verzenio (abemaciclib) (CDK4/6 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Abstract 4851: Combination of letrozole plus abemaciclib is synergistic and suppresses tumor growth in ovarian and endometrial cancer models
Published date:
05/15/2020
Excerpt:
Conversely, the RB-mutated cell line, A2780 was unresponsive to either drug alone or to combination therapy, and an antagonistic interaction (CI>1) was observed.
DOI:
10.1158/1538-7445.AM2020-4851