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Association details:
| Biomarker: | RB1 mutation |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug Class: | Immunotherapy |
| Direction: | Resistant |
Evidence:
Source:
Title:
RB1 aberrations predict outcomes of immune checkpoint inhibitor combination therapy in NSCLC
Published date:
07/13/2023
Excerpt:
We enrolled 53 NSCLC patients treated with ICI combination therapy and collected their tissue and plasma samples to perform next-generation sequencing (NGS) with a 425-gene panel....Patients with mutated RB1 had shorter PFS than those with wild RB1 (134d vs 219d, p=0.018).
DOI:
10.3389/fonc.2023.1172728
