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Association details:
| Biomarker: | RB1 mutation |
|---|---|
| Cancer: | Bladder Cancer |
| Drug: | Keytruda (pembrolizumab) (PD1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Comprehensive biomarker analyses and updated results of PURE-01 study: Neoadjuvant pembrolizumab (pembro) in muscle-invasive urothelial bladder carcinoma (MIBC)
Published date:
10/01/2018
Excerpt:
Pembro is given 200mg q3w x3 cycles. Pathologic complete response (pT0) in ITT population is the primary endpoint (EP)….RB1 and PBRM1 GA were significantly associated with pT0 (p = 0.014 and p = 0.007).
DOI:
https://doi.org/10.1093/annonc/mdy283.075
Trial ID:
