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    Association details:
    Biomarker:PTPRD V253I + PTPRD W775stop
    Cancer:Ewing Sarcoma
    Drug Class:mTOR inhibitor +
    IGF-1R inhibitor
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    New
    Source:
    Oncotarget
    Title:

    Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications

    Excerpt:
    We identified a novel germline mutation in the PTPRD gene in three of eight patients (37.5%) with metastatic Ewing sarcoma…Patients with Ewing sarcoma tested for germline mutations in PTPRD and outcomes with IGF-1R-based therapy.
    DOI:
    10.18632/oncotarget.1021