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Association details:
Biomarker:PTPRD V253I + PTPRD W775stop
Cancer:Ewing Sarcoma
Drug Class:IGF-1R inhibitor
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Source:
Title:

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications

Excerpt:
We identified a novel germline mutation in the PTPRD gene in three of eight patients (37.5%) with metastatic Ewing sarcoma….Of interest, two of three patients with germline PTPRD mutations achieved durable complete responses following treatment with IGF-1R monoclonal antibody-based therapies...Patients with Ewing sarcoma tested for germline mutations in PTPRD and outcomes with IGF-1R-based therapy.
DOI:
10.18632/oncotarget.1021