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Association details:
| Biomarker: | PTPN11 mutation |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | Tibsovo (ivosidenib) (IDH1 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Molecular Mechanisms Mediating Relapse Following Ivosidenib Monotherapy in Patients with IDH1-Mutant Relapsed or Refractory Acute Myeloid Leukemia
Published date:
11/06/2019
Excerpt:
Baseline mutations in the individual RTK pathway genes of NRAS and PTPN11, and in the RTK pathway genes as a group (defined in this analysis as NRAS, KRAS, PTPN11, KIT, and FLT3), were associated with a significantly lower likelihood of achieving a best response of CR or CRh with ivosidenib (P = .004, P = .016, and P < .001, respectively; Fisher’s exact test; Figure 2B), suggesting a role in primary treatment resistance.
DOI:
https://doi.org/10.1182/bloodadvances.2020001503
Trial ID:
