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Association details:
| Biomarker: | PTGR1 expression |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | hydroxyureamethylacylfulvene (STAR-001) (Alkylating agent) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The acylfulvene alkylating agent, LP-184, retains nanomolar potency in non-small cell lung cancer carrying otherwise therapy-refractory mutations
Published date:
04/13/2021
Excerpt:
...we found that LP-184 sensitivity in the NSCLC cell lines tested correlates with PTGR1 transcript levels (Pearson Correlation Coefficient, r = –0.603, p value 6.076E-05)....PTGR1 expression was compared among two groups of NSCLC cell lines tested: 11 cell lines with LP-184 IC50 < 571 nM and 8 cell lines with IC50 > 571 nM. As displayed in Figure 2B, PTGR1 transcript levels turned out to be significantly different (p value 0.017) in these cell line groups....PTGR1 gene expression is still moderately but significantly correlated with LP-184 sensitivity (Figure 2A). This suggests that PTGR1 is likely to be a primary causal determinant underlying LP-184 sensitivity prediction.
DOI:
10.18632/oncotarget.27943
