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Association details:
Biomarker:PTEN mutation
Cancer:Endometrial Cancer
Drug:GSK2636771 (PI3Kβ inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
New
Title:

PI3K pathway dependencies in endometrioid endometrial cancer cell lines

Excerpt:
PTEN-mutant EEC cell lines were resistant to the p110β inhibitors GSK2636771 and AZD6482, and only in combination with the p110α selective inhibitor A66, a decrease in cell viability was observed.... treatment with the p110β isoform-specific inhibitors GSK2636771, AZD6482 and TGX-221 or the p110α isoform-specific inhibitor A66 revealed that the EEC cell lines tested were resistant to these agents...
DOI:
10.1158/1078-0432.CCR-12-3815