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Association details:
| Biomarker: | PTEN mutation |
|---|---|
| Cancer: | Endometrial Cancer |
| Drug: | A66 (PI3K inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
PI3K pathway dependencies in endometrioid endometrial cancer cell lines
Excerpt:
PTEN-mutant EEC cell lines were resistant to the p110β inhibitors GSK2636771 and AZD6482, and only in combination with the p110α selective inhibitor A66, a decrease in cell viability was observed....Our results fail to corroborate these observations in EEC cell lines, as single-agent treatment with the three different p110β selective inhibitors tested (i.e. GSK2636771, AZD6482 and TGX-221) and the p110α inhibitor A66 did not sensitize EEC cells.
DOI:
10.1158/1078-0432.CCR-12-3815
