^
Association details:
| Biomarker: | PTEN deletion |
|---|---|
| Cancer: | Prostate Cancer |
| Drug: | MEN1611 (PI3K inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The Selective Class I PI3K Inhibitor CH5132799 Targets Human Cancers Harboring Oncogenic PIK3CA Mutations
Excerpt:
...in the PTEN-deficient model, gastric cancer GXF97 tumors in which the PTEN gene was deleted were shrunk remarkably by CH5132799 administration, and tumor growth was inhibited in a PC-3 prostate cancer model.
DOI:
10.1158/1078-0432.CCR-10-2882
