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Association details:
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Title:

Pharmacodynamic Effects and Mechanisms of Resistance to Vemurafenib in Patients With Metastatic Melanoma

Excerpt:
PTEN expression at baseline was higher in responders versus nonresponders (P = .042; Fig 2). Despite this, PRs were still observed in four (36%) of 11 patients with a complete loss of nuclear PTEN expression. Figure 3 shows the reduction in tumor size in patients receiving vemurafenib during BRIM-2 by PTEN expression...
DOI:
10.1200/JCO.2012.44.7888
Trial ID: