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Association details:
| Biomarker: | PTEN deletion |
|---|---|
| Cancer: | Melanoma |
| Drug: | GSK2636771 (PI3Kβ inhibitor) + ENUM004 (OX40 ligand inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kß Inhibition in PTEN Loss Melanoma
Excerpt:
...combining anti-OX40 with GSK2636771, a PI3Kβ-selective inhibitor, delayed tumor growth and extended the survival of mice with PTEN-null melanomas.
DOI:
10.1158/1078-0432.CCR-19-1259
