^
Association details:
| Biomarker: | PTEN deletion |
|---|---|
| Cancer: | Melanoma |
| Drug: | CI-1040 (MEK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Whole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibition
Excerpt:
...in the 22 092 cells, PTEN was not expressed and AKT phosphorylation was elevated (Figure (Figure4A).4A)...Accordingly, PD184352 and MK2206 synergised to inhibit the growth of 22 092 cells in long-term proliferation assays (Figure (Figure4D),4D), and when the cells were grown in suspension (Figure (Figure44E).
DOI:
10.1093/annonc/mdu049
