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    Association details:
    Biomarker:PTEN deletion
    Cancer:Chordoma
    Drug Class:PDGFR inhibitor
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    PLoS One
    Title:

    Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

    Excerpt:
    Chordoma cells deficient for PTEN show increased in vitro growth and resistance to PDGFR inhibition...However, PTEN deficient tumors showed greater resistance to PDGFR inhibition on invasion…
    DOI:
    10.1371/journal.pone.0134426