^
Association details:
| Biomarker: | PTEN deletion |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | Piqray (alpelisib) (PIK3CA inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Convergent loss of PTEN leads to clinical resistance to a PI3Ka inhibitor
Excerpt:
Targeted exome sequencing identified homozygous loss of PTEN in a post-treatment sample of a breast cancer patient who developed resistance to BYL719 after initially experiencing a durable response to therapy.
DOI:
10.1038/nature13948
