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Association details:
| Biomarker: | PTCH1 deletion |
|---|---|
| Cancer: | Medulloblastoma |
| Drug: | saridegib oral (IPI 926 oral) (Hedgehog cell-signalling pathway inhibitor, SMO protein inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model
Excerpt:
...pilot study to evaluate the efficacy of saridegib in 21-dold PtcC/C mice with clinical evidence of medulloblastoma…a strong response to saridegib therapy, with decreased cerebellar tumor size in treated mice...mice treated with daily saridegib for 6 wk (Fig. 2, dashed line) survived...
DOI:
10.1073/pnas.1114718109
