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Association details:
| Biomarker: | PRC2 mutation |
|---|---|
| Cancer: | T Acute Lymphoblastic Leukemia |
| Drug: | JQ-1 (BET inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
BETTING ON PRC2 ALTERATION IN T CELL ACUTE LYMPHOBLASTIC LEUKEMIA
Published date:
05/14/2020
Excerpt:
We treated T-ALL PDXs with the BET protein inhibitor JQ1 and showed that PRC2-altered PDXs are more sensitive than wild-type PDXs to BET inhibition.
