The patient with colorectal cancer harbored a novel POMK‐NRG1 fusion and a KRAS mutation….In May 2018, the patient underwent lung metastasectomies. Caris® (Irving, TX) NGS profiling identified a novel POMK‐NRG1 fusion in both lung and liver metastases….Afatinib 30 mg/day was initiated in September 2018, with a reduction in CEA from 190 μg/mL to 163 μg/mL observed in October 2018 (Fig. ​(Fig.2).2). In November 2018, a CT scan showed SD, and the CEA was 292 μg/mL.