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    Association details:
    Biomarker:PLK1 overexpression
    Cancer:Renal Cell Carcinoma
    Drug:Sutent (sunitinib) (c-KIT inhibitor, VEGFR inhibitor, PDGFR inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: C3 – Early Trials
    Source:
    Commun Biol
    Title:

    Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma

    Published date:
    02/05/2021
    Excerpt:
    High Plk1 expression conferred a resistant phenotype of ccRCC to targeted therapeutics such as sunitinib, in vitro, in vivo, and in metastatic ccRCC patients
    DOI:
    10.1038/s42003-021-01653-w