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    Association details:
    Biomarker:PLK1 overexpression
    Cancer:Estrogen Receptor Positive Breast Cancer
    Drug:anastrozole (Aromatase inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Nat Commun
    Title:

    PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance

    Published date:
    08/13/2020
    Excerpt:
    Finally, in two independent clinical cohorts of ER positive BC, we find a strong association between high expression of PLK1 and a shorter metastases-free survival and poor response to anastrozole.
    DOI:
    10.1038/s41467-020-17697-1