^
Association details:
| Biomarker: | PIK3CA mutation |
|---|---|
| Cancer: | Squamous Cell Carcinoma of Head and Neck |
| Drug Class: | PD1 inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
685P - Genomic characteristics and immunotherapy outcomes in patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC)
Published date:
09/05/2022
Excerpt:
Interestingly, PIK3CA alteration was negatively correlated with OS (HR 1.99, P = 0.027), while TERT promoter mutation showed a positive correlation with OS (HR 0.44, P = 0.05)....Our single institution data with anti-PD-1 ICB Tx in R/M HNSCC is consistent with registration study results. The correlation between PIK3CA and TERT promoter gene alterations and ICB outcome warrants further investigation.
