...explored the in vitro efficacy of drug combinations (ribociclib and alpelisib (R+A)) in four CRC cell lines with different mutational status; CACO-2 (PIK3CA/KRAS wildtype), LS-1034 (KRAS mutated), SNU-C4 (PIK3CA mutated), and DLD-1 (PIK3CA/KRAS mutated) cells....Drug combination analysis showed that combination of R+A has a synergistic anti-proliferative effect in all CRC cell lines tested.