^
Association details:
| Biomarker: | PIK3CA mutation + PTEN mutation + KRAS mutation |
|---|---|
| Cancer: | Endometrial Cancer |
| Drug: | pictilisib (GDC-0941) (PI3K inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
PI3K pathway dependencies in endometrioid endometrial cancer cell lines
Excerpt:
...a subset of EEC cell lines tested here harboring coexisting PIK3CA/KRAS or PIK3CA/PTEN/KRAS mutations were GDC-0941 responsive (Fig. 2A).
DOI:
10.1158/1078-0432.CCR-12-3815
