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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

Relationship between Tumor Biomarkers and Efficacy in EMILIA, a Phase III Study of Trastuzumab Emtansine in HER2-Positive Metastatic Breast Cancer

Excerpt:
At concentrations ≥0.01 μg/mL, sensitivity to T-DM1 was observed across all cell lines with various activating PIK3CA mutations (Fig. 3).
DOI:
10.1158/1078-0432.CCR-15-2499