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Association details:
Biomarker:PIK3CA E545K
Cancer:Breast Cancer
Drug:CYH33 (PIK3CA inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C4 – Case Studies
Source:
Title:

33O A phase I study to evaluate safety, pharmacokinetics (PK), and preliminary efficacy of CYH33, a phosphatidylinositol 3-kinase a (PI3Ka) inhibitor, in patients (pts) with advanced solid tumours

Published date:
03/01/2021
Excerpt:
Other 3 pts with partial response (PR) were found in 1 OC pt (PIK3CA E545K mutation), 1 BC pt (PIK3CA E545K mutation), and 1 gastric cancer (PIK3CA E542K mutation)....CYH33 demonstrates a manageable safety profile and linear pharmacokinetic characteristics.
DOI:
https://doi.org/10.1016/j.annonc.2021.01.048
Trial ID: