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Association details:
Biomarker:PGBD5 overexpression
Cancer:Neuroblastoma
Drug:cisplatin (DNA synthesis inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors

Excerpt:
...for PDX2 neuroblastoma tumor, which had relatively high PGBD5 expression (Fig. 7B), we observed significant reduction in tumor growth upon single-agent AZD6738 and cisplatin treatment, as compared to vehicle control (P = 0.032 and 0.079, respectively; Fig. 7D).
DOI:
10.1126/scitranslmed.aam9078