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Association details:
Biomarker:PD-L1 elevation
Cancer:Urothelial Cancer
Drug Class:Immunotherapy
Direction:Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
New
Source:
Title:

Soluble PD-L1 is a predictive and prognostic biomarker in advanced cancer patients who receive immune checkpoint blockade treatment

Published date:
10/05/2021
Excerpt:
This study aimed to investigate the significance of sPD-L1 in cancer patients receiving immune checkpoint inhibitor therapy....The study cohort consisted of 128 patients who were diagnosed with non-small cell lung cancer (n = 50), melanoma (n = 31), small cell lung cancer (n = 14), urothelial carcinoma (n = 13), and other cancers (n = 20)....In the multivariate analyses, high sPD-L1 was an independent prognostic factor for both decreased PFS (HR 1.928, p = 0.038) and OS (HR 1.788, p = 0.004).
DOI:
10.1038/s41598-021-99311-y