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Association details:
| Biomarker: | PARP1 underexpression |
|---|---|
| Cancer: | Soft Tissue Sarcoma |
| Drug Class: | ATR inhibitor + PARP1 inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
6277 - Identification of ATR inhibitors as therapeutic opportunities in Desmoplastic small round cell tumors
Published date:
03/09/2022
Excerpt:
Drug sensitivity screen evaluating 80 cancer-relevant small molecule inhibitors in dose-response was performed on the JN-DSRCT-1 (JN1) cell line....Sensitivity to ATRi was revalidated in the JN1 and R cell lines, whereas sensitivity to PARPi was only revalidated in the JN1 cell line - consistent with the very low PARP1 expression in that cell line....Combination experiments revealed that both drugs were synergistic in the JN1 cell line.
