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Association details:
Biomarker:PARP1 underexpression
Cancer:Soft Tissue Sarcoma
Drug Class:ATR inhibitor +
PARP1 inhibitor
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

6277 - Identification of ATR inhibitors as therapeutic opportunities in Desmoplastic small round cell tumors

Published date:
03/09/2022
Excerpt:
Drug sensitivity screen evaluating 80 cancer-relevant small molecule inhibitors in dose-response was performed on the JN-DSRCT-1 (JN1) cell line....Sensitivity to ATRi was revalidated in the JN1 and R cell lines, whereas sensitivity to PARPi was only revalidated in the JN1 cell line - consistent with the very low PARP1 expression in that cell line....Combination experiments revealed that both drugs were synergistic in the JN1 cell line.