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Association details:
| Biomarker: | PAK4 overexpression |
|---|---|
| Cancer: | Solid Tumor |
| Drug Class: | PD1 inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
PAK4 Inhibition Increases Anti-PD-1 Response in Mouse Models Prompting Phase I Trial
Published date:
12/09/2019
Excerpt:
In tumors with relatively little T cell infiltration or infiltration by antigen-presenting dendritic cells….We found that biopsies of patients who did not respond to PD-1 blockade showed an overexpression of PAK4
