^
Association details:
| Biomarker: | PAK4 deletion |
|---|---|
| Cancer: | Solid Tumor |
| Drug Class: | PD1 inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
PAK4 inhibition improves PD-1 blockade immunotherapy
Excerpt:
It has been postulated that cancer cell-intrinsic mechanisms may actively exclude T cells from tumors...In mouse models, genetic deletion of PAK4 increased T cell infiltration and reversed resistance to PD-1 blockade in a CD8 T cell-dependent manner.
DOI:
10.1038/s43018-019-0003-0
