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    Association details:
    Biomarker:NTRK3 fusion
    Cancer:Ampulla of Vater Carcinoma
    Drug:Rozlytrek (entrectinib) (ALK inhibitor, TrkB receptor inhibitor, TrkC kinase inhibitor, TrkA receptor inhibitor, ROS1 inhibitor, JAK2 inhibitor, TNK2 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: A2 - Guideline
    New
    Source:
    NCCN
    Published date:
    04/27/2023
    Excerpt:
    Ampullary Adenocarcinoma...Good PS….Targeted Systemic Therapies:...Useful in Certain Circumstances:...Entrectinib (if NTRK gene fusion positive).
    Evidence Level:
    Sensitive: C1 - Off-label
      (Approved for Solid Tumor)
    Excerpt:
    ROZLYTREK is a kinase inhibitor indicated for the treatment of...Adult and pediatric patients older than 1 month of age with solid tumors that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion, as detected by an FDA-approved test without a known acquired resistance mutation.