^
Association details:
| Biomarker: | NPM1 mutation |
|---|---|
| Cancer: | Leukemia |
| Drug: | EPZ004777 (DOT1L inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia
Excerpt:
...we assessed the effect of EPZ4777, a small-molecule DOT1L inhibitor in NPM1mut leukemias. DOT1L-inhibition (DOT1L-i) led to a profound reduction in cell proliferation and colony-forming potential in the human and both murine NPM1mut leukemia models...DOT1L-i resulted in significant repression of HOX genes in human and murine leukemia cells...
DOI:
10.1158/2159-8290.CD-16-0237
