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Association details:
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

Factors Impacting Response to Olutasidenib in Patients with mIDH1 Acute Myeloid Leukemia

Published date:
11/02/2023
Excerpt:
More patients with R132C (58%) and R132L/G/S (48%) mutations achieved an overall response compared to those with an R132H mutation (26%)...Although fewer patients in the overall responder groups had FLT3 or NPM1 mutations compared with the non-responder group, 12/38 (32%) with NPM1 and 5/16 (31%) with FLT3 had an overall response....This post-hoc analysis demonstrated that response to olutasidenib occurred across a wide variety of patient types and disease characteristics...
DOI:
https://doi.org/10.1182/blood-2023-178804