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GENE:

NOTCH4 (Notch 4)

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NOTCH4 mutation	Non Small Cell Lung Cancer	NOTCH4 mutation	Non Small Cell Lung Cancer	tislelizumab-jsgr Sensitive: B - Late Trials tislelizumab-jsgr Sensitive : B	tislelizumab-jsgr Sensitive: B - Late Trials tislelizumab-jsgr Sensitive : B
TP53 mutation + NOTCH4 mutation	Non Small Cell Lung Cancer	TP53 mutation + NOTCH4 mutation	Non Small Cell Lung Cancer	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3
NOTCH1 expression + NOTCH4 expression	Estrogen Receptor Positive Breast Cancer	NOTCH1 expression + NOTCH4 expression	Estrogen Receptor Positive Breast Cancer	Immunotherapy Resistant: C3 – Early Trials Immunotherapy Resistant : C3	Immunotherapy Resistant: C3 – Early Trials Immunotherapy Resistant : C3
NOTCH4 expression	Estrogen Receptor Positive Breast Cancer	NOTCH4 expression	Estrogen Receptor Positive Breast Cancer	Immunotherapy Resistant: C3 – Early Trials Immunotherapy Resistant : C3	Immunotherapy Resistant: C3 – Early Trials Immunotherapy Resistant : C3
NRAS wild-type + NOTCH4 mutation	Melanoma	NRAS wild-type + NOTCH4 mutation	Melanoma	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3