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Association details:
| Biomarker: | NOTCH1 mutation |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug: | Ogsiveo (nirogacestat) (γ-secretase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
PEST domain mutations in Notch receptors comprise an oncogenic driver segment in triple-negative breast cancer sensitive to a ?-secretase inhibitor
Published date:
03/15/2015
Excerpt:
We identified three PDX models all of which had distinct genomic rearrangements that truncated the PEST domain of NOTCH1 or NOTCH2...All three models were highly sensitive to PF-03084014, including more than 50% tumor regression in the MAXF1162 model, which was similar to the NOTCH1 ECD deleted HCC1599 cell line xenograft model previously known to be sensitive to GSI (Fig. 2B; refs. 33, 34).
DOI:
10.1158/1078-0432.CCR-14-1348
