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Association details:
| Biomarker: | NOTCH1 mutation |
|---|---|
| Cancer: | Squamous Cell Carcinoma of Head and Neck |
| Drug: | WNT974 (Wnt signalling pathway inhibitor, PORCN inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
Excerpt:
One of the most striking results of our study was the correlation of aggregated LoF Notch1 mutations with responsiveness to LGK974.
DOI:
10.1073/pnas.1314239110
