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Association details:
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
Source:
Title:

Multi-omics analysis of mantle cell lymphoma reveals an immune-cold tumor microenvironment associated with ibrutinib resistance.

Published date:
05/29/2020
Excerpt:
NOTCH1 gain-of-function mutations (25%, 3/12 resistant) in the PEST domain were found exclusively in the ibrutinib-resistant cohort associated with the microenvironment-depleted subtype....PD-L1 was significantly downregulated in the ibrutinib-resistant MCL tumors (p = 0.03)...
DOI:
10.1200/JCO.2020.38.15_suppl.8055