Melanoma: Cutaneous...Systemic Therapy for Metastatic or Unresectable Disease...First-line therapy; Other recommended regimens...Pembrolizumab/low-dose ipilimumab (category 2B) added as an option...Second-line or subsequent therapy; Systemic therapy; Preferred regimens...Pembrolizumab/low-dose ipilimumab or tumors that have progressed after prior anti-PD-1 therapy added as an option.