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    Association details:
    Biomarker:No biomarker
    Cancer:B Acute Lymphoblastic Leukemia
    Drug:vincristine (Tubulin polymerization inhibitor) +
    prednisone (Steroid receptor agonist) +
    daunorubicin (Topoisomerase II inhibitor, DNA intercalator) +
    Oncaspar liquid (pegaspargase) (Asparagine depleter, Aspartate-ammonia ligase inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: A2 - Guideline
    Source:
    NCCN
    Published date:
    04/04/2022
    Excerpt:
    Acute Lymphoblastic Leukemia...Preferred Regimens...CALGB 10403 regimen: daunorubicin, vincristine, prednisone, and pegaspargase