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Association details:
Biomarker:
NF2 E108X
Cancer:
Neurofibrosarcoma
Drug:
everolimus
(
mTOR inhibitor
)
Direction:
Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
Source:
ASCO 2021
Title:
Next generation sequencing of sarcomas: Response to crizotinib in two cases with MET amplification.
Published date:
05/19/2021
Excerpt:
Table summarizes matched therapies in responders....Malignant peripheral nerve sheath tumor...NF2: E108*...Temsirolimus + cyclophosphamide + vinorelbine – PR, 13 mo. Everolimus - PD.
DOI:
10.1200/JCO.2021.39.15_suppl.11538
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