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Association details:
| Biomarker: | NF1 underexpression |
|---|---|
| Cancer: | Neuroblastoma |
| Drug: | Mektovi (binimetinib) (MEK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression
Excerpt:
...Cell lines sensitive to binimetinib treatment had the lowest NF1 protein levels, while resistant cell lines showed the highest levels of NF1 protein…Fig 5…
DOI:
10.1186/s12885-016-2199-z
