^
Association details:
| Biomarker: | NF1 mutation |
|---|---|
| Cancer: | Melanoma |
| Drug: | VTX-11e (ERK2 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition
Excerpt:
We also tested the effect of pharmacologic ERK inhibition in this setting using the compound VTX-11e (29). Interestingly, B-RAFV600E melanoma cells harboring NF1 knockdown remained sensitive to ERK inhibition (Figure 5C).
DOI:
10.1158/2159-8290.CD-12-0470
