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BIOMARKER:

NF1 mutation

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NF1 mutation	Solid Tumor	NF1 mutation	Solid Tumor	selumetinib Resistant: C2 – Inclusion Criteria selumetinib Resistant : C2	selumetinib Resistant: C2 – Inclusion Criteria selumetinib Resistant : C2
NF1 mutation	CNS Tumor	NF1 mutation	CNS Tumor	selumetinib Sensitive: C3 – Early Trials selumetinib Sensitive : C3	selumetinib Sensitive: C3 – Early Trials selumetinib Sensitive : C3
NF1 mutation	Glioma	NF1 mutation	Glioma	trametinib Sensitive: C3 – Early Trials trametinib Sensitive : C3	trametinib Sensitive: C3 – Early Trials trametinib Sensitive : C3
NF1 mutation	Melanoma	NF1 mutation	Melanoma	vemurafenib Resistant: C3 – Early Trials vemurafenib Resistant : C3	vemurafenib Resistant: C3 – Early Trials vemurafenib Resistant : C3
NF1 mutation	Thyroid Gland Anaplastic Carcinoma	NF1 mutation	Thyroid Gland Anaplastic Carcinoma	atezolizumab + cobimetinib Sensitive: C3 – Early Trials atezolizumab + cobimetinib Sensitive : C3	atezolizumab + cobimetinib Sensitive: C3 – Early Trials atezolizumab + cobimetinib Sensitive : C3
NF1 mutation	Colorectal Cancer	NF1 mutation	Colorectal Cancer	AZD6738 Sensitive: C3 – Early Trials AZD6738 Sensitive : C3	AZD6738 Sensitive: C3 – Early Trials AZD6738 Sensitive : C3
NF1 mutation	Multiple Myeloma	NF1 mutation	Multiple Myeloma	MEK inhibitor Sensitive: C3 – Early Trials MEK inhibitor Sensitive : C3	MEK inhibitor Sensitive: C3 – Early Trials MEK inhibitor Sensitive : C3
NF1 mutation	Melanoma	NF1 mutation	Melanoma	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3
NF1 mutation	Melanoma	NF1 mutation	Melanoma	PD1 inhibitor + MEK inhibitor Sensitive: C3 – Early Trials PD1 inhibitor + MEK inhibitor Sensitive : C3	PD1 inhibitor + MEK inhibitor Sensitive: C3 – Early Trials PD1 inhibitor + MEK inhibitor Sensitive : C3
NF1 mutation	Thyroid Gland Medullary Carcinoma	NF1 mutation	Thyroid Gland Medullary Carcinoma	vandetanib Sensitive: C4 – Case Studies vandetanib Sensitive : C4	vandetanib Sensitive: C4 – Case Studies vandetanib Sensitive : C4
NF1 mutation	Sarcoma	NF1 mutation	Sarcoma	SAR442720 Sensitive: C4 – Case Studies SAR442720 Sensitive : C4	SAR442720 Sensitive: C4 – Case Studies SAR442720 Sensitive : C4
NF1 mutation	Melanoma	NF1 mutation	Melanoma	VTX-11e Resistant: D – Preclinical VTX-11e Resistant : D	VTX-11e Resistant: D – Preclinical VTX-11e Resistant : D
NF1 mutation	Melanoma	NF1 mutation	Melanoma	PD-0325901 Sensitive: D – Preclinical PD-0325901 Sensitive : D	PD-0325901 Sensitive: D – Preclinical PD-0325901 Sensitive : D
NF1 mutation	Neurofibrosarcoma	NF1 mutation	Neurofibrosarcoma	DR6MP + JHU395 Sensitive: D – Preclinical DR6MP + JHU395 Sensitive : D	DR6MP + JHU395 Sensitive: D – Preclinical DR6MP + JHU395 Sensitive : D
NF1 mutation	Neurofibrosarcoma	NF1 mutation	Neurofibrosarcoma	DR6MP Sensitive: D – Preclinical DR6MP Sensitive : D	DR6MP Sensitive: D – Preclinical DR6MP Sensitive : D
NF1 mutation	Neurofibrosarcoma	NF1 mutation	Neurofibrosarcoma	MEK inhibitor + c-MET inhibitor Sensitive: D – Preclinical MEK inhibitor + c-MET inhibitor Sensitive : D	MEK inhibitor + c-MET inhibitor Sensitive: D – Preclinical MEK inhibitor + c-MET inhibitor Sensitive : D
NF1 mutation	Non Small Cell Lung Cancer	NF1 mutation	Non Small Cell Lung Cancer	ERAS-601 Sensitive: D – Preclinical ERAS-601 Sensitive : D	ERAS-601 Sensitive: D – Preclinical ERAS-601 Sensitive : D
NF1 mutation	Melanoma	NF1 mutation	Melanoma	cobimetinib Sensitive: D – Preclinical cobimetinib Sensitive : D	cobimetinib Sensitive: D – Preclinical cobimetinib Sensitive : D