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Association details:
Biomarker:NF1 mutation
Cancer:Melanoma
Drug:Cotellic (cobimetinib) (MEK1 inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

Bromodomain inhibition overcomes treatment resistance in distinct molecular subtypes of melanoma

Published date:
08/15/2022
Excerpt:
Combinatorial therapy involving bromosporine and cobimetinib (bromo/cobi) showed synergistic anti-tumor effects in multiple BRAFi-resistant PDX models. The bromo/cobi combination was superior in vivo to standard BRAFi/MEKi therapy in the treatment-naive BRAF-mutant setting and to MEKi alone in the setting of immunotherapy-resistant NRAS- and NF1-mutant melanoma.
DOI:
10.1073/pnas.2206824119