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Association details:
| Biomarker: | NF1 470G>T |
|---|---|
| Cancer: | Glioblastoma |
| Drug: | bisindolylmaleimide IX (RO-31-8220) (PKC inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis
Excerpt:
Consistent with data from GBM cell lines, the TS543 cultures were exquisitely sensitive to PKC inhibitors, while the TS565 cultures were relatively insensitive (Extra sum of squares F-test, P=4.657.10-6) (Figure 5F). Taken together these data suggest that PKC may represent a potential therapeutic target in GBMs in which the NF1 gene is intact and the protein is destabilized.
DOI:
10.1016/j.ccr.2009.05.009
