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Association details:
| Biomarker: | NCOR1-LYN fusion |
|---|---|
| Cancer: | B Acute Lymphoblastic Leukemia |
| Drug: | sirolimus (mTOR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Leukemic Cell Expressing a Novel Kinase Fusion Protein NCOR1-LYN Exhibits High Sensitivity to Dasatinib and Rapamycin
Published date:
11/01/2018
Excerpt:
Consistent with our hypothesis, cytotoxic assay revealed that rapamycin (20nM) could suppress the proliferation of Ba/F3 cells expressing NCOR1-LYN efficiently compared to Ba/F3 cells not expressing NCOR1-LYN.
DOI:
10.1182/blood-2018-99-111612
