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BIOMARKER:
MYD88 L265P
i
Other names:
MYD88, MYD88 Innate Immune Signal Transduction Adaptor, Myeloid Differentiation Primary Response Protein MyD88, Myeloid Differentiation Primary Response Gene (88), Myeloid Differentiation Primary Response 88, Mutant Myeloid Differentiation Primary Response 88, MYD88D
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Entrez ID:
4615
Related biomarkers:
Expression
Mutation
Others
‹
MYD88 mutation (19)
MYD88 L265P + BRAF V600E (2)
MYD88 L265P + CD79B mutation (2)
MYD88 mutation + CXCR4 mutation (2)
MYD88 L265P + CXCR4 mutation (1)
MYD88 mutation + CD79B mutation (1)
MYD88 wild-type (1)
BTK C481S + MYD88 mutation (0)
MYD88 mutation (19)
MYD88 L265P + BRAF V600E (2)
MYD88 L265P + CD79B mutation (2)
MYD88 mutation + CXCR4 mutation (2)
MYD88 L265P + CXCR4 mutation (1)
MYD88 mutation + CD79B mutation (1)
MYD88 wild-type (1)
BTK C481S + MYD88 mutation (0)
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Trials
VERI cancer hierarchy
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MYD88 L265P
Waldenstrom Macroglobulinemia
MYD88 L265P
Waldenstrom Macroglobulinemia
zanubrutinib
Sensitive: B - Late Trials
zanubrutinib
Sensitive
:
B
zanubrutinib
Sensitive: B - Late Trials
zanubrutinib
Sensitive
:
B
MYD88 L265P
Waldenstrom Macroglobulinemia
MYD88 L265P
Waldenstrom Macroglobulinemia
rituximab + ixazomib
Sensitive: C2 – Inclusion Criteria
rituximab + ixazomib
Sensitive
:
C2
rituximab + ixazomib
Sensitive: C2 – Inclusion Criteria
rituximab + ixazomib
Sensitive
:
C2
MYD88 L265P
Waldenstrom Macroglobulinemia
MYD88 L265P
Waldenstrom Macroglobulinemia
venetoclax
Sensitive: C3 – Early Trials
venetoclax
Sensitive
:
C3
venetoclax
Sensitive: C3 – Early Trials
venetoclax
Sensitive
:
C3
MYD88 L265P
Lymphoma
MYD88 L265P
Lymphoma
ibrutinib
Sensitive: C3 – Early Trials
ibrutinib
Sensitive
:
C3
ibrutinib
Sensitive: C3 – Early Trials
ibrutinib
Sensitive
:
C3
MYD88 L265P
Marginal Zone Lymphoma
MYD88 L265P
Marginal Zone Lymphoma
ibrutinib
Sensitive: C3 – Early Trials
ibrutinib
Sensitive
:
C3
ibrutinib
Sensitive: C3 – Early Trials
ibrutinib
Sensitive
:
C3
MYD88 L265P
Waldenstrom Macroglobulinemia
MYD88 L265P
Waldenstrom Macroglobulinemia
daratumumab
Sensitive: C3 – Early Trials
daratumumab
Sensitive
:
C3
daratumumab
Sensitive: C3 – Early Trials
daratumumab
Sensitive
:
C3
MYD88 L265P
Diffuse Large B Cell Lymphoma
MYD88 L265P
Diffuse Large B Cell Lymphoma
rituximab
Resistant: C3 – Early Trials
rituximab
Resistant
:
C3
rituximab
Resistant: C3 – Early Trials
rituximab
Resistant
:
C3
MYD88 L265P
Waldenstrom Macroglobulinemia
MYD88 L265P
Waldenstrom Macroglobulinemia
mavorixafor
Sensitive: C3 – Early Trials
mavorixafor
Sensitive
:
C3
mavorixafor
Sensitive: C3 – Early Trials
mavorixafor
Sensitive
:
C3
MYD88 L265P
Waldenstrom Macroglobulinemia
MYD88 L265P
Waldenstrom Macroglobulinemia
orelabrutinib
Sensitive: C3 – Early Trials
orelabrutinib
Sensitive
:
C3
orelabrutinib
Sensitive: C3 – Early Trials
orelabrutinib
Sensitive
:
C3
MYD88 L265P
Non-Hodgkin’s Lymphoma
MYD88 L265P
Non-Hodgkin’s Lymphoma
rituximab
Resistant: C3 – Early Trials
rituximab
Resistant
:
C3
rituximab
Resistant: C3 – Early Trials
rituximab
Resistant
:
C3
MYD88 L265P
Diffuse Large B Cell Lymphoma
MYD88 L265P
Diffuse Large B Cell Lymphoma
Sensitive: C3 – Early Trials
Sensitive
:
C3
Sensitive: C3 – Early Trials
Sensitive
:
C3
MYD88 L265P
Multiple Myeloma
MYD88 L265P
Multiple Myeloma
lenalidomide + bortezomib
Sensitive: C4 – Case Studies
lenalidomide + bortezomib
Sensitive
:
C4
lenalidomide + bortezomib
Sensitive: C4 – Case Studies
lenalidomide + bortezomib
Sensitive
:
C4
MYD88 L265P
Diffuse Large B Cell Lymphoma
MYD88 L265P
Diffuse Large B Cell Lymphoma
KT-413
Sensitive: D – Preclinical
KT-413
Sensitive
:
D
KT-413
Sensitive: D – Preclinical
KT-413
Sensitive
:
D
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